Cheilitis Glandularis Is a Common Developmental Anomaly
Cheilitis granulomatosa is a chronic granulomatous condition, characterized clinically by soft, painless, nonpitting swelling of the lower lip. In some cases, the lip lesions may also present scaling, fissuring, cracking or vesiculation, etc. Cheilitis granulomatosa is sometimes considered to be the milder form of "Melkersson-Rosenthal syndrome".
Microscopy shows a noncascjp graiiuloma with epithelioid cells and Langhan cells, within the connective tissue stroma. Perivasive and paravascular aggregation of lymphocytes, plasma cells and histiocytes are also common. There is no specific treatment for this condition.
Peutz-Jeghers syndrome is characterized by small melanotic patches on the oral mucosa, which are associated with similar lesions around the mouth, nose and eyes, etc. Skin pigmentations usually fade away after puberty but the oral pigmentations persist. The other important feature of the syndrome is the occurrence of multiple intestinal polyps, which may cause pain and obstruction very often.
Microscopy shows a noncascjp graiiuloma with epithelioid cells and Langhan cells, within the connective tissue stroma. Perivasive and paravascular aggregation of lymphocytes, plasma cells and histiocytes are also common. There is no specific treatment for this condition.
Peutz-Jeghers syndrome is characterized by small melanotic patches on the oral mucosa, which are associated with similar lesions around the mouth, nose and eyes, etc. Skin pigmentations usually fade away after puberty but the oral pigmentations persist. The other important feature of the syndrome is the occurrence of multiple intestinal polyps, which may cause pain and obstruction very often.
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