Cheilitis Glandularis Is a Common Developmental Anomaly

Cheilitis Glandularis Is a Common Developmental Anomaly

Cheilitis glandularis is a developmental anomaly, characterized by chronic enlargement of the labial salivary glands, which cause eversion of the lower lip and is commonly seen among young males. Clinically, the labial glands become nodular and hard, having studded with red openings on the mucosal surface, that exude viscous mucus.
The exact cause of the disease is unknown, however heredity and exposure to sun, dust, wind or tobacco, etc. may play some role in its pathogenesis.
The histologic section of the lesion under microscope reveals hyperplasia of the salivary glands, with infiltration by plasma cells and lymphocytes. No specific treatment is available for this disease and the usual practice is to use some protective ointments. But as the lesion is considered as a precancerous one, vermiionectomy may sometimes be considered.
Cheilitis granulomatosa is a chronic granulomatous condition, characterized clinically by soft, painless, nonpitting swelling of the lower lip. In some cases, the lip lesions may also present scaling, fissuring, cracking or vesiculation, etc. Cheilitis granulomatosa is sometimes considered to be the milder form of "Melkersson-Rosenthal syndrome".
Microscopy shows a noncascjp graiiuloma with epithelioid cells and Langhan cells, within the connective tissue stroma. Perivasive and paravascular aggregation of lymphocytes, plasma cells and histiocytes are also common. There is no specific treatment for this condition.